P4220Mild cellular heart transplant rejection is associated with decreased myocardial mitochondrial respiration and coupling efficiency
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Cisplatin cytotoxicity is dependent on mitochondrial respiration in Saccharomyces cerevisiae
Objective(s): To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells. Materials and Methods: Wild type and Rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, pH changes ...
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OBJECTIVE To identify relationships between insulin resistance (IR) and mitochondrial respiration in perinatally HIV-infected youth. DESIGN Case-control study. METHODS Mitochondrial respiration was assessed in perinatally HIV-infected youth in Tanner stages 2-5, 25 youth with IR (IR+) and 50 without IR (IR-) who were enrolled in the Pediatric HIV/AIDS Cohort Study. IR was defined as a homeo...
متن کاملAcute cellular rejection in pediatric heart transplant recipients is associated with abnormal left ventricular mechanics by CMR
Methods 18 combined cardiac magnetic resonance (CMR)/endomyocardial biopsies were performed in 14 HTX patients (11 male, age 13.9 ± 4.7 years (2.4-17.9 years); 1.2 ± 1.3 years (12 days-5.0 years) after HTX). Biventricular function and left ventricular (LV) circumferential strain, rotation and torsion by CMR were compared to 11 controls. To adjust for repeated measurements in 2 HTX patients, Wal...
متن کاملMyocardial ischemic-fibrotic injury after human heart transplantation is associated with increased progression of vasculopathy, decreased cellular rejection and poor long-term outcome.
OBJECTIVES We sought to assess the influence of peritransplant ischemia and fibrosis on the development of allograft vasculopathy, acute cellular rejection and long-term outcome. BACKGROUND Allograft vasculopathy is a common long-term complication of cardiac transplantation. One of the potential risk factors is peritransplant allograft ischemia. METHODS One hundred forty heart transplant re...
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OBJECTIVS Cytokine-dependent activation of fibroblasts to myofibroblasts, a key event in fibrosis, is accompanied by phenotypic changes with increased secretory and contractile properties dependent on increased energy utilization, yet changes in the energetic profile of these cells are not fully described. We hypothesize that the TGF-β1-mediated transformation of myofibroblasts is associated wi...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2018
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehy563.p4220